Sertraline Impurity 50 HCl CAS 122873-20-5 (free base)
| CAS No. | 122873-20-5 (free base) |
| Molecular Formula | C18H19Cl2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sertraline Impurity 50 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Sertraline Impurity 50 HCl (CAS 122873-20-5 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C18H19Cl2NHCl and a molecular weight of 356.71 g/mol.
Structurally, Sertraline Impurity 50 HCl (C18H19Cl2NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 356.71 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H19Cl2N HCl |
| Molecular Weight | 356.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline - Impurity C (Freebase) (CAS 107538-91-0)
- Sertraline Acetamide (CAS 1097616-52-8)
- Sertraline Carbamoyl Glucuronide (CAS 119733-44-7)
- Sertraline Impurity 26 (CAS 1198115-10-4（free base）)
- Sertraline RC 11 (CAS 1217630-23-3)
- Sertraline-d3 Hydrochloride (CAS 1217741-83-7)
- Sertraline EP Impurity F Enantiomer (CAS 124379-29-9)
- (±)-trans-Sertraline-d3 HCl (N-methyl-d3) (CAS 1330180-66-9)
Recommended Standards
- Bumetanide Impurity 33 (CAS 28395-28-0)
- Vericiguat impurity 46 (CAS CATO-C4X-289646)
- Sorafenib Impurity 32 (CAS 50528-86-4)
- 4-(((1,2,3,4-Tetrahydronaphthalen-1-yl)amino)methyl)-7,8-dihydrocyclopenta[g]chromen-2(6H)-one (CAS 869469-29-4)
- [2,6-Dimethyl-4-(3-[2-(Z-amino)-ethylcarbamoyl]-propoxy)-benzenesulfonyl]-Dap(Boc)-OMe (CAS 277316-24-2)
- Bis(5-nitropyridin-2-yl)sulfane (CAS 2127-11-9)
- 2-(3-Chloro-4-methoxyphenyl)-6-methyl-2H-benzo[d][1,2,3]triazol-5-amine (CAS 356085-76-2)
- 5-Fluoroquinazolin-4-yl acetate (CAS 866009-24-7)
- 3-Methyl-2-nitropyridin-4-ol (CAS 1806581-55-4)
- Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 75976-10-2)
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